研究業績他

図書

Manami Tanaka and  Tomoo Tanaka ‘Huaier  Natural Herb Therapy for Cancer’, Bradeion Institute of Medical Sciences, Co., Ltd. March 2022. ISBN: 978-4-9912525-0-1.(ここをクリックすると、Amazonでの購入ページ(書籍ならびに電子書籍の両方あり)にアクセスできます

画像はKindle版、電子書籍です。本文はすべて英語です。ペーパーバックス版、紙の書籍もあります。

 

田中朝雄・真奈実 著 「槐耳」療法 自力でゲノム治癒力 第2版 2023/3/14 ブラディオン医科学研究所(ここをクリックすると、Amazonでの購入ページ(オンデマンド書籍ならびに電子書籍の両方あり)にアクセスできます

画像はペーパーバックス、紙の書籍の案内です。電子書籍もあります。

論文(下のジャーナル名部分をクリックすると、オリジナル論文にアクセスできます。以下も同様です。)

1. Manami Tanaka, Tomoo Tanaka, Fei Teng, Xiaolong Zhu, Hong Lin, Zhu Luo, Sotaro Sadahiro, Toshiyuki Suzuki, Yuji Maeda, Ding Wei and Zhengxin Lu. Huaier Effects on Prevention and Inhibition of Spontaneous SARS-CoV-2 Virion Production by Repeated Pfizer-BioNTech mRNA Vaccination. Archives of Clinical and Medical Case Reports 7 (2023): 20-38. (2023年1月24日に掲載されたばかりの論文です)
2. Manami Tanaka, Tomoo Tanaka, Xiaolong Zhu, Fei Teng, Hong Lin, Zhu Luo, Ying Pan, Sotaro Sadahiro, Toshiyuki Suzuki, Yuji Maeda, Ding Wei, Zhengxin Lu. Hair growth and restoration by transcriptional control of tissue regeneration in cancer recovery process by HuaierJournal of Cancer Science and Clinical Therapeutics, 6(3)288-316, 2022. (掲載日:2022年8月12日)

3. Manami Tanaka, Tomoo Tanaka, Xiaolong Zhu, Fei Teng, Hong Lin, Zhu Luo, Ying Pan, Sotaro Sadahiro, Toshiyuki Suzuki, Yuji Maeda, Ding Wei, Zhengxin Lu. Huaier Effects on Functional Compensation with Destructive Ribosomal RNA Structure after Anti-SARS-CoV-2 mRNA Vaccination. Archives of Clinical and Biomedical Research, 6, 553-574, 2022. (掲載日:2022年6月22日)

4. Manami Tanaka, Tomoo Tanaka, Fei Teng, Hong Lin, Zhu Luo, Sotaro Sadahiro, Toshiyuki Suzuki, Ding Wei, Zhengxin Lu. Biomedicine in 21st century: The practical health maintenance and successful recovery from cancer. Journal of Biomedicine and Biosensores. 1, 33-56, (2021).

5. Manami Tanaka, Tomoo Tanaka, Fei Teng, Hong Lin, Ning Li, Zhu Luo, Sotaro Sadahiro, Toshiyuki Suzuki, Ding Wei, Zhengxin Lu. Huaier Therapy for Successful Recovery of Cancer and Health Maintenance: Steady Progress and the End of Failed Promise. Archives of Clinical and Biomedical Research. 5, 457-483, 2021.

6. Manami Tanaka, Tomoo Tanaka, Fei Teng, Hong Lin, Ning Li, Zhu Luo, Sotaro Sadahiro, Toshiyuki Suzuki, Ding Wei, Zhengxin Lu. Huaier compensates impaired signal transfer inter/intra neuronsin central and peripheral nervous systems. Archives of Clinical and Biomedical Research. 5, 484-518, 2021.

7. Manami Tanaka, Tomoo Tanaka, Fei Teng, Hong Lin, Ning Li, Zhu Luo, Ding Wei and Zhengxin Lu. Huaier Inhibits Cancer Progression and Induces Tissue Regeneration by Transcriptional Regulation of Pluripotency of Stem Cells.  Journal of Alternative, Complementary & Integrative Medicine. 7, 162-170, 2021.

8. Manami Tanaka, Tomoo Tanaka, Fei Teng, Hong Lin, Ning Li, Zhu Luo, Ding Wei and Zhengxin Lu. Huaier Inhibits Cancer Progression Correlated with the Mutated EGFR and Other Receptor Tyrosine Kinases (c-MET/erbB-2) by Down-Regulation of Multiple Signal Transduction Pathways. Archives of Clinical and Biomedical Research. 5, 262-284, 2021.

9. Manami Tanaka, Tomoo Tanaka, Fei Teng, Hong Lin, Ning Li, Zhu Luo, Sotaro Sadahiro, Toshiyuki Suzuki, Ding Wei and Zhengxin Lu. Complete remission of the severe advanced stage cancer by miRNA-mediated transcriptional control of Bcl-xL with Huaier therapy compared to the conventional chemotherapy with platinum (II) complex. Archives of Clinical and Biomedical Research. 5, 230-261, 2021.

10. Manami Tanaka, Tomoo Tanaka, Fei Teng, Hong Lin, Ning Li, Zhu Luo, Ding Wei, and Zhengxin Lu.  Anti-cancer effects of Huaier on prostate cancer; miRNA-mediated transcription control induced both inhibition of active progression and prevention of relapse.  Journal of Alternative, Complementary & Integrative Medicine. 7, 146-154, 2021.

11. Manami Tanaka, Tomoo Tanaka, Fei Teng, Hong Lin, Ning Li, Zhu Luo, Ding Wei, and Zhengxin Lu. Huaier Induces Cancer Recovery by Rescuing Impaired Function of Transcription Control Based On the Individual Genomic Potential. Archives of Clinical and Biomedical Research. 4, 817-855, 2020.

12. 田中真奈実, 田中朝雄.  大容量ゲノム解析の時代ー次世代マーカー医療の開始ー槐耳抗癌効果の分子基盤. 創薬のひろば, 13, 54-67, 2020.

2020秋 創薬のひろば(オリジナルを見るには、←をクリックしてください)

13. 田中真奈実, 田中朝雄.  癌治癒の分子基盤:驚異的ゲノム柔軟性と遺伝子機能回復. 創薬のひろば, 11,32-39, 2019.

2019秋 創薬のひろば(オリジナルを見るには、←をクリックしてください)

14. 田中真奈実.  癌治療近未来 –ソリューションから始まる生体現象解明の曙光.  創薬のひろば, 7, 40-43, 2017.

2017秋 創薬のひろば (オリジナルを見るには、←をクリックしてください)

15. Tomoo Tanaka, Takayoshi Suzuki, Jun Nakamura, Yoshiaki Kawamura, Sotaro Sadahiro, Hiroshi Kijima, Itaru Yamamoto, Nicole Vo, Masamitsu Yamaguchi, Yasuhiro Irino, Masakazu Shinohara, Ding We, & Manami Tanaka. Huaier Regulates Cell Fate by the Rescue of Disrupted Transcription Control in the Hippo Signaling Pathway. Archives of Clinical and Biomedical Research, 1 (4), 179-199, 2017.

16. Tanaka Tomoo, Kawamura, Y., Usui, Y., Terachi, T., Kimura, F., Asano, T., Hayakawa, M., Sakai, N., Morimoto, S., Mogi, Y., Fujiwara, H., Yamamoto, N., Komori, K. & Tanaka Manami. Bradeion Project: Monitoring and Targeting of Cancer: Molecular Marker Diagnosis of Cancer by Fluorescence Correlation Spectroscopy (FCS). The Open Conference Proceedings Journal, 1, 129-136, 2010.

17. Garcia, W., Rodrigues, N. C., Lara, F., Foguel, D., Tanaka Manami, Tanaka Tomoo & Garratt, R.C. The stability and aggregation properties of the GTPase domain from human septin 4 (SEPT4/Bradeion-beta). Biochimica et Biophysica Acta (BBA) _ Proteins and Proteomics, 1784, 1720-1727, 2008.

18. Garcia, W., de Ara_jo A.P.U., Lara, F., Foguel, D., Tanaka Manami, Tanaka Tomoo & Garratt, R.C. An intermediate structure in the thermal unfolding of the GTPase domain of human septin 4 (SEPT4/Bradeion-β) forms amyloid-like filaments in vitro. Biochemistry, 46, 11101-11109 , 2007.

19. Garcia, W., Hillebrand, S., Araujo, A.P.U., Carrilho, E., Tanaka Manami, Tanaka Tomoo, and Garratt, R.C. Characterization of the GTPase activity in the recombinant Human Septin SEPT4 (Bradeion β) Biochemistry. 45, 13918-13931, 2006.

20. Hillebrand, S., Carcia, W., Cantu, M.D., Ulian de Araújo, Tanaka Manami, Tanaka Tomoo, Garrat, R. C., Carrilho, E. In vitro monitoring of GTPase activity and enzyme kinetics studies using capillary electrophoresis. Analytical and Bioanalytical Chemistry, 383, 92-97, 2005.

21. Risa M.F. Cardoso, Carlos H.T.P. Silva, Ana Paula Ulin de Araujo, Tomoo Tanaka, Manami Tanaka, Richard C. Garratt (2004) Structure of the cytosolic Cu, Zn superoxide dismutase from Schistosoma mansoni. Acta Crystallographica D60, 1569-1578.

22. Manami Tanaka, Tomoo Tanaka, Hiroshi Kijima, Johbu Itoh, Taroh Matsuda, Kiyoshi Komori, Yasuhiro Seto, Sizuo Misse, Seiichiro Matsuzaki, Yasunobu Hashimoto & Hiroshi Tohma (2003) Rapid and quantitative detection of a mammalian septin Bradeion as a practical diagnostic method of colorectal and urologic cancers. Med. Sci. Moni. 9 (7) MT61-68.

23. Ian G. Macara, Richard Baldarelli, Christine M. Field, Michael Glotzer, Yasuhide Hayashi, Shu-Chan Hsu, Mary B. Kennedy, Makoto Kinoshita, Mark Longtine,Claudia Low, Lois J. Maltais, Louise McKenzie, Timothy J. Mitchison, Toru Nishikawa, Makoto Noda, Elizabeth M. Petty, Mark Peifer, John R. Pringle, PhillipJ. Robinson, Dagmar Roth, S.E. Hilary Russell, Heidi Stuhlmann, Manami Tanaka, Tomoo Tanaka, William S. Trimble, Jerry Ware, Nancy J. Zeleznik-Le, BarbaraZieger (2002) Mammalian Septin Nomenclature. Molecular Biology of the Cell, 13, 4111-4113.

24. Manami Tanaka, Hiroshi Kijima, Johbu Itoh, Taroh Matsuda and Tomoo Tanaka (2002) Impaired expression of a human septin family gene Bradeion inhibits the growth and tumorigenesis of colorectal cancer in vitro and in vivo. Cancer Gene Therapy, 9 (6), 483-488.

25. Rosa M. D. Cardoso, Carlos H.T.P. da Silva, Ana P.U. de Araujo, Tomoo Tanaka, Manami Tanaka and Richard C. Garratt (2001) Expression and preliminary X-ray diffraction studies of cytosolic Cu, Zn superoxide dismutase from Schistosoma mansoni. Acta Crystallographica Section D, 57, 1877-1880.

26. Tanaka Manami, Tanaka Tomoo, Kijima H, Itoh J, Matsuda T, Hori S and Yamamoto M (2001) Characterization of Tissue- and Cell Type-Specific Expression of a Novel Human Septin Family Gene Bradeion. Biochem. Biophy Res Commun., 286, 547-553.

 

当社研究者の共同研究
1. 2016年7月1日〜2017年3月31日 京都工芸繊維大学昆虫先端研究推進センター共同研究「癌補完療法の研究:ショウジョウバエモデルを用いた癌抑制機構再活性化をもたらす遺伝子機序の解明」

当社研究者の獲得研究助成金
1. 2016年〜2018年度 日本学術振興会 基盤研究 (C)「進行癌の予防と治療補完療法の研究:発症前診断法及び癌抑制機構再活性化の検討」

2. 2010~2012年度 日本学術振興会 基盤研究(C)「ヒトセプチン4ブラディオンGTPaseを標的とした抗癌剤開発の研究」

3. 2006~2007年度 日本学術振興会 基盤研究(C) 「細胞分裂機能計測および制御技術による癌対策技術開発」

4. 2003~2004年度 日本学術振興会 基盤研究(C)「大腸癌モニターシステム開発」

5. 2000~2001年度 日本学術振興会 基盤研究(C)「大腸癌特異的発現遺伝子Bradeionの機能解明と臨床応用技術開発」

6. 1996~1998年度 文部省 科学研究費補助金 試験研究(B)(1)(次年度より基盤研究 (A)(1))「異種生物間情報伝達機構の制御技術開発」