{"id":39,"date":"2015-06-18T17:10:15","date_gmt":"2015-06-18T08:10:15","guid":{"rendered":"http:\/\/bradeion.com\/wp\/?page_id=39"},"modified":"2016-07-28T15:28:52","modified_gmt":"2016-07-28T06:28:52","slug":"%e5%8c%bb%e5%b8%ab%e7%a0%94%e7%a9%b6%e8%80%85%e3%81%b8","status":"publish","type":"page","link":"https:\/\/www.bradeion.com\/wp\/%e5%8c%bb%e5%b8%ab%e7%a0%94%e7%a9%b6%e8%80%85%e3%81%b8\/","title":{"rendered":"\u533b\u5e2b\u7814\u7a76\u8005\u3078"},"content":{"rendered":"
\n
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\n

SEPT4\uff08\u30d2\u30c8\u30bb\u30d7\u30c1\u30f3\uff14\uff09\u306a\u3089\u3073\u306bSETP4\u6e2c\u5b9a\u306b\u3064\u3044\u3066\u306e\u89e3\u8aac
\n<\/span><\/p>\n

\u4eba\u9593\u30c9\u30c3\u30af\u3067\u306f40\u4ee3\u5f8c\u534a\u306730\uff05\u304c\u967d\u6027\u3068\u3055\u308c\u308b\u5927\u8178\u764c\u306e\u65e9\u671f\u75c5\u5909\u3002\u5b9f\u969b\u306b\u691c\u8a3a\u3067\u7570\u5e38\u3092\u691c\u77e5\u3067\u304d\u308b\u306e\u306f\u305d\u306e1\/10\u306b\u3057\u304b\u904e\u304e\u307e\u305b\u3093\u3002\uff19\u5272\u306e\u65b9\u304c\u898b\u843d\u3068\u3055\u308c\u3001\u9032\u884c\u764c\u306b\u306a\u3063\u3066\u521d\u3081\u3066\u75c5\u9662\u3092\u53d7\u8a3a\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u7e70\u308a\u8fd4\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002SEPT4\u6e2c\u5b9a\u3067\u306f\u3001\u5fae\u91cf\u306e\u8840\u6db2\u3067\u898b\u843d\u3068\u3057\u306a\u304f\u75c5\u5909\u3092\u5bdf\u77e5\u3057\u3001\u5185\u8996\u93e1\u691c\u67fb\u30fb\u6cbb\u7642\u3067\u6e08\u3080\u6bb5\u968e\u3067\u898b\u3064\u3051\u308b<\/span>\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u307e\u305f\u3001\u30dd\u30ea\u30fc\u30d7\u9664\u53bb\u7b49\u3067\u6cbb\u7642\u5f8c\uff12\u9031\u9593\u4ee5\u5185\u306b100\uff05\u3001SEPT4\uff08\u30d2\u30c8\u30bb\u30d7\u30c1\u30f3\uff14\uff09\u5024\u304c\u6b63\u5e38\u5316\u3059\u308b\u305f\u3081\u3001\u6cbb\u7652\u5224\u5b9a\u3082\u3067\u304d\u308b<\/span>\u3068\u3044\u3046\u5229\u70b9\u304c\u3042\u308a\u307e\u3059\u3002\u9ad8\u9f62\u8005\u7537\u6027\u304c\u4e0d\u5b89\u306b\u601d\u3046\u524d\u7acb\u817a\u764c\u3082\u3001\u751f\u691c\u3084\u5207\u9664\u304c\u5fc5\u8981\u304b\u3069\u3046\u304b\u3001\u5ba2\u89b3\u7684\u306b\u6570\u5024\u3067\u77e5\u308b\u3053\u3068\u304c\u51fa\u6765\u307e\u3059\u3002PSA\u8a08\u6e2c\u3082\u5165\u3063\u3066\u3044\u308b\u305f\u3081\u3001\u4ed6\u306e\u691c\u67fb\u306e\u4f75\u7528\u3082\u4e0d\u8981\u3067\u3059\u3002\u814e\u764c\u30de\u30fc\u30ab\u30fc\u3001\u3055\u3089\u306b\u3001SEPT4\u9670\u6027\u764c\u30de\u30fc\u30ab\u30fc\u3082\u540c\u6642\u8a08\u6e2c\u3057\u3066\u304a\u308a\u307e\u3059\u306e\u3067\u3001\uff11\u56de\u306e\u63a1\u8840\u3067\u5f97\u3089\u308c\u308b\u60c5\u5831\u91cf\u306f\u3068\u3066\u3082\u591a\u304f\u3001\u65e2\u306b\u764c\u3068\u8a3a\u65ad\u3055\u308c\u3066\u6cbb\u7642\u4e2d\u306e\u65b9\u3082\u3001\u73fe\u5728\u306e\u764c\u306e\u72b6\u614b\u3084\u8ee2\u79fb\u3084\u85ac\u5264\u611f\u53d7\u6027\u306a\u3069\u3001\u4ed6\u306e\u60c5\u5831\u3092\u5408\u308f\u305b\u3066\u77e5\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n

(1)<\/span>SEPT4\u306f\u5927\u8178\u764c\u30fb\u76ae\u819a\u764c\u306a\u3069\u3067\u4f5c\u3089\u308c\u308b<\/p>\n

\"BradedionNorhternFig1\"<\/a><\/p>\n

<\/div>\n

\u56f31. \u30d2\u30c8\u57f9\u990a\u764c\u7d30\u80de\u62bd\u51fa\u4f1d\u9054RNA\u4e2dSEPT4. \u77e2\u5370\u3067\u793a\u3057\u305f\u30d0\u30f3\u30c9\u304c\u3001\u305d\u306e\u57f9\u990a\u764c\u7d30\u80de\u4e2d\u306bSEPT4\u907a\u4f1d\u5b50\u304c\u4f5c\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u5927\u8178\u764c\u3068\u76ae\u819a\u764c\u3067\u306fSEPT4\u907a\u4f1d\u5b50\u304c\u3001SEPT4\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u308b\u305f\u3081\u306b\u4f5c\u3089\u308c\u3066\u3044\u308b<\/span>\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\uff08\u4f1d\u9054RNA\uff1a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u308b\u30a2\u30df\u30ce\u9178\u914d\u5217\u3092\u6c7a\u5b9a\u3059\u308b\u30ea\u30dc\u6838\u9178\uff09<\/p>\n

\u3000\u7d44\u307f\u63db\u3048SEPT4\u30fb\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u6210\u3057\u3001\u305d\u308c\u306b\u5bfe\u3059\u308b\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3092\u4f5c\u6210\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n

\"\"<\/span>\u56f32. \u57f9\u990a\u5927\u8178\u764c\u7d30\u80de\u306b\u5bfe\u3059\u308b\u6297SEPT4\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u306e\u53cd\u5fdc. \u4e0a\u304a\u3088\u3073\u5de6\u4e0b\u3067\u7dd1\u306b\u5149\u3063\u3066\u3044\u308b\u306e\u306f\u57f9\u990a\u5927\u8178\u764c\u7d30\u80de\u3067\u3001\u53f3\u4e0b\u306e\u307b\u3068\u3093\u3069\u5149\u3063\u3066\u3044\u306a\u3044\u306e\u306f\u57f9\u990a\u4e73\u764c\u7d30\u80de\u3067\u3059\u3002\u3064\u307e\u308a\u3001\u4f5c\u6210\u3057\u305f\u6297SEPT4\u30fb\u30e2\u30ce\u30af\u30fc\u30ed\u30ca\u30eb\u6297\u4f53\u306f\u5927\u8178\u764c\u306b\u53cd\u5fdc\u3057\u3001\u4e73\u764c\u306b\u306f\u53cd\u5fdc\u3057\u307e\u305b\u3093\u3002\u3064\u307e\u308a\u3001<\/span>SEPT4\u306f\u5927\u8178\u764c\u3067\u306f\u4f5c\u3089\u308c\u3066\u3044\u308b<\/span>\u304c\u3001\u4e73\u764c\u3067\u306f\u4f5c\u3089\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u3092\u8a3c\u660e\u3057\u305f\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/span><\/span><\/p>\n

(2)<\/span>SEPT4\u306f\u764c\u306e\u5897\u6b96\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b<\/span><\/p>\n

\"\"<\/p>\n<\/div>\n<\/div>\n<\/div>\n

\n
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\u56f33. \u5927\u8178\u764c\u57f9\u990a\u7d30\u80de\u3092\u76ae\u4e0b\u6ce8\u5c04\u3057\u305f\u30cc\u30fc\u30c9\u30de\u30a6\u30b9\u306b\u6297SEPT4\u6a5f\u80fd\u6027\u6838\u9178\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u306b\u3088\u308b\u764c\u306e\u5897\u6b96\u6291\u5236. \u30ea\u30dc\u30b6\u30a4\u30e0\u3068\u30de\u30ad\u30b7\u30b6\u30a4\u30e0: <\/span>\u6a5f\u80fd\u6027\u6838\u9178<\/span>\u3068\u547c\u3070\u308c\u3001\u76ee\u7684\u3068\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8a2d\u8a08\u56f3\u3067\u3042\u308b\u4f1d\u9054RNA\uff08\u30ea\u30dc\u6838\u9178\uff09\u3068\u76f8\u88dc\u3059\u308b\u6838\u9178\u3092\u7d30\u80de\u5185\u306b\u5c0e\u5165\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u4f1d\u9054RNA\u3092\u50cd\u304b\u306a\u304f\u3057\u3066\u3001\u305d\u306e\u7d50\u679c\u3068\u3057\u3066\u76ee\u7684\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u3089\u305b\u306a\u3044\u3088\u3046\u306b\u3059\u308b\u3082\u306e. \u3053\u3053\u3067\u306e\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306fSEPT4\u3067\u3001\u56f3\uff11\u306e\u3088\u3046\u306b<\/span>alpha<\/span>\u3068<\/span>beta<\/span>\u306e\u4e8c\u7a2e\u985e\u3042\u308a\u3001\u305d\u306e\u907a\u4f1d\u5b50\u914d\u5217\u306e\u524d\u534a\u304c\u4e00\u81f4\u3057\u3066\u3044\u308b\u305f\u3081\u3001<\/span>alpha<\/span>\u306e\u307f\u3092\u50cd\u304b\u305b\u306a\u304f\u3059\u308b\u305f\u3081\u306b\u30de\u30ad\u30b7\u30b6\u30a4\u30e0\u3068\u3044\u3046\u30ea\u30dc\u30b6\u30a4\u30e0\u3068\u306f\u7570\u306a\u308b\u6a5f\u80fd\u6027\u6838\u9178\u3092\u4f5c\u6210\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u56f3\u304b\u3089\u3001\u30cc\u30fc\u30c9\u30de\u30a6\u30b9\u306b\u79fb\u690d\u3057\u305f\u5927\u8178\u764c\u7d30\u80de\u306f\u7121\u51e6\u7406\u304a\u3088\u3073\u5a92\u4ecb\u907a\u4f1d\u5b50\u306e\u307f\u304c\u5c0e\u5165\u3055\u308c\u305f\u30de\u30a6\u30b9\u3067\u306f\u764c\u7d30\u80de\u304c\u7740\u5b9f\u306b\u5897\u6b96\u3057\u3066\u3044\u308b\u306e\u306b\u5bfe\u3057\u3001\u30ea\u30dc\u30b6\u30a4\u30e0\u306e\u307f\u306e\u3082\u306e\u306f\u7d30\u80de\u5897\u6b96\u3092\u3042\u308b\u7a0b\u5ea6\u6291\u5236\u3057\u3001\u30ea\u30dc\u30b6\u30a4\u30e0\u3068\u30de\u30ad\u30b7\u30b6\u30a4\u30e0\u306e\u4e21\u65b9\u304c\u5c0e\u5165\u3055\u308c\u305f\u3082\u306e\u306f\u5897\u6b96\u304c\u307b\u3068\u3093\u3069\u8a8d\u3081\u3089\u308c\u305a\u3001<\/span>\u7d30\u80de\u5897\u6b96\u304c\u5236\u6b62\u3055\u308c\u3066\u3044\u308b<\/span>\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u3001SEPT4\u304c\u4f5c\u3089\u308c\u308b\u3053\u3068\u3092\u963b\u6b62\u3059\u308b\u3053\u3068\u3067\u764c\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u3001\u3064\u307e\u308a\u3001<\/span>SEPT4\u306f\u764c\u6cbb\u7642\u306e\u6a19\u7684\u3068\u306a\u308b<\/span>\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

(3)<\/span>SEPT4\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u3067\u764c\u306e\u767a\u898b\u304c\u53ef\u80fd<\/p>\n

\n
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\"\"<\/div>\n


\n<\/span><\/p>\n<\/div>\n

\u56f34. \u5927\u8178\u764c\u30fb\u6ccc\u5c3f\u5668\u764c\u7d44\u7e54\u62bd\u51fa\u7dcfRNA\u4e2dSEPT4\uff08\u30d2\u30c8\u30bb\u30d7\u30c1\u30f3\uff14\uff09.
\n<\/span><\/p>\n

\u6a2a\u8ef8\uff1a\u6a2a\u8ef8\u5404\u5de6\u306e\u30ea\u30dc\u30be\u30fc\u30e0\u30bf\u30f3\u30d1\u30af\u8cea10 (RPL10) \u306f\u5b9f\u9a13\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb. \u53f3\u306fSEPT4\u6e2c\u5b9a. \u7e26\u8ef8\uff1a\u7dcfRNA\uff08\u30ea\u30dc\u6838\u9178\uff091 \u03bcg SEPT<\/span>4\u4e2d\u306b\u542b\u307e\u308c\u308bRPL10\u307e\u305f\u306fSEPT4\u4f1d\u9054RNA\u306e\u91cf\u3067\u3001\u5b9a\u91cfRT-PCR\uff08\u9006\u8ee2\u5199–<\/span>\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u9396\u53cd\u5fdc\uff09\u3067\u6975\u5fae\u91cf\u306e\u76ee\u7684\u3068\u3059\u308b\u4f1d\u9054RNA\u91cf\u3092\u6e2c\u5b9a\u3059\u308b\u6280\u8853\u3067\u5f97\u3089\u308c\u307e\u3059\u3002\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306eRPL10\u306f\u5168\u3066\u306e\u7d30\u80de\u306e\u50cd\u304d\u306b\u5fc5\u8981\u306e\u305f\u3081\u3001\u4f1d\u9054RNA\u91cf\u306f\u591a\u3044\u3002SEPT4\u306fRPL10\u307b\u3069\u591a\u304f\u306f\u7d30\u80de\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u764c\u3067\u306f\u4f5c\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002\u5de6\u304b\u3089\uff12\u756a\u76ee\u3068\u4e00\u756a\u53f3\u306e\u6a2a\u8ef8\u3067\u307b\u3068\u3093\u3069\uff10\u3092\u793a\u3057\u3066\u3044\u308b\u306e\u306f\u3001\u826f\u6027\u816b\u760d\u306e\u7d50\u679c\u3067\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u3059\u3079\u3066\u306e\u5927\u8178\u764c\u30fb\u8180\u80f1\u764c\u30fb\u814e\u764c\u30fb\u524d\u7acb\u817a\u764c\u3067SEPT4\u304c\u591a\u304f\u4f5c\u3089\u308c\u3066\u3044\u308b<\/span>\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002
\n<\/span><\/p>\n

\u00a02. \u5b9f\u969b\u306eSEPT4\u691c\u67fb
\n<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
\n
\n

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\n<\/span><\/p>\n

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\"\"<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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